Interaction of alpha(1)-Na,K-ATPase and Na,K,2Cl-cotransporter genes in human essential hypertension.

@article{Glorioso2001InteractionOA,
  title={Interaction of alpha(1)-Na,K-ATPase and Na,K,2Cl-cotransporter genes in human essential hypertension.},
  author={Nicola Glorioso and Fabiana Filigheddu and Chiara Troffa and A. A. Soro and Paolo Pinna Parpaglia and Aristides Tsikoudakis and Richard H. Myers and Victoria L. M. Herrera and Nelson Ruiz-Opazo},
  journal={Hypertension},
  year={2001},
  volume={38 2},
  pages={204-9}
}
Essential hypertension is a common disease the genetic determinants of which have been difficult to unravel because of its clinical heterogeneity and complex, multifactorial, polygenic etiology. Based on our observations that alpha(1)-Na,K-ATPase (ATP1A1) and renal-specific, bumetanide-sensitive Na,K,2Cl-cotransporter (NKCC2) genes interactively increase susceptibility to hypertension in the Dahl salt-sensitive hypertensive (Dahl S) rat model, we investigated whether parallel molecular genetic… CONTINUE READING