Interaction of agitoxin2, charybdotoxin, and iberiotoxin with potassium channels: Selectivity between voltage‐gated and Maxi‐K channels

@article{Gao2003InteractionOA,
  title={Interaction of agitoxin2, charybdotoxin, and iberiotoxin with potassium channels: Selectivity between voltage‐gated and Maxi‐K channels},
  author={Yinghong Gao and Maria L. Garcia},
  journal={Proteins: Structure},
  year={2003},
  volume={52}
}
To gain insight into the molecular determinants that define the specificity of interaction of pore‐blocking peptides, such as agitoxin 2 (AgTX2), charybdotoxin (ChTX), and iberiotoxin (IbTX) with the Shaker‐type voltage‐gated potassium channel Kv1.3, or the large‐conductance Ca2+‐activated K+ (Maxi‐K) channel, homology models of these channels were generated based on the crystal structure of the bacterial, KcsA, potassium channel. Peptide–channel complexes were analyzed to evaluate the… Expand
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TLDR
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