Interaction of age and APOE genotype on cerebral blood flow at rest.

  title={Interaction of age and APOE genotype on cerebral blood flow at rest.},
  author={Christina E. Wierenga and Lindsay R. Clark and Sheena I. Dev and David D Shin and Sarah M. Jurick and Robert A Rissman and Thomas T. Liu and Mark W. Bondi},
  journal={Journal of Alzheimer's disease : JAD},
  volume={34 4},
We investigated the impact of APOE genotype on cerebral blood flow (CBF) in older and younger adults. Forty cognitively normal older adults (16 ε4 carriers, 24 non-ε4 carriers) and 30 younger adults (15 ε4 carriers, 15 non-ε4 carriers) completed a resting-state whole-brain pulsed arterial spin labeling magnetic resonance scan. Main effects of aging were demonstrated wherein older adults had decreased gray matter CBF corrected for partial volume effects compared to younger adults in widespread… CONTINUE READING
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