Interaction of adipocyte fatty acid-binding protein (AFABP) and JAK2: AFABP/aP2 as a regulator of JAK2 signaling.

@article{Thompson2009InteractionOA,
  title={Interaction of adipocyte fatty acid-binding protein (AFABP) and JAK2: AFABP/aP2 as a regulator of JAK2 signaling.},
  author={Brian R Thompson and Anna M Mazurkiewicz-Mu{\~n}oz and J. Timothy Suttles and Christin Carter-Su and David A Bernlohr},
  journal={The Journal of biological chemistry},
  year={2009},
  volume={284 20},
  pages={13473-80}
}
Adipocyte fatty acid-binding protein (AFABP/aP2) facilitates the intracellular solubilization and trafficking of lipids within the aqueous environment of the cell. Studies in the AFABP/aP2 knock-out mouse suggest that the protein may have roles in cellular processes broader than lipid transport. We present herein the finding that AFABP/aP2 interacts with JAK2 in a fatty acid-dependent manner. This interaction was established using yeast two-hybrid analysis, co-immunoprecipitation from adipose… CONTINUE READING
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