Interaction of adenine nucleotides, UTP and suramin in mouse vas deferens: suramin-sensitive and suramin-insensitive components in the contractile effect of ATP

@article{Kgelgen1990InteractionOA,
  title={Interaction of adenine nucleotides, UTP and suramin in mouse vas deferens: suramin-sensitive and suramin-insensitive components in the contractile effect of ATP},
  author={Ivar von K{\"u}gelgen and Ralph B{\"u}ltmann and Klaus Starke},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
  year={1990},
  volume={342},
  pages={198-205}
}
Effects of various nucleotides, nucleosides and noradrenaline on smooth muscle tension were studied in the isolated mouse vas deferens. α,β-Methylene-ATP, ATPγS, noradrenaline, ATP and UTP elicited contraction, with potency decreasing in that order; there was no contractile response to adenosine or uridine (up to 100 μmol/l). Prolonged incubation with α,β-methylene-ATP (concentration increased stepwise from 0 to 15 μmol/l) selectively reduced contractions induced by ATP and UTP but not those… CONTINUE READING
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