Interaction of a polymeric biguanide biocide with phospholipid membranes.

  title={Interaction of a polymeric biguanide biocide with phospholipid membranes.},
  author={Tokuji Ikeda and Anthony Ledwith and Clare Bamford and R. A. Hann},
  journal={Biochimica et biophysica acta},
  volume={769 1},
Differential scanning calorimetry (DSC) and fluorescence polarization methods have been used to study the interactions between phospholipid membranes and a polymeric biocide, poly(hexamethylene biguanide hydrochloride) (PHMB). It was found that PHMB had very little effect on neutral lipids such as phosphatidylcholine (PC) and phosphatidylethanolamine (PE), whereas it greatly reduced the phase transition temperature of phosphatidylglycerol (PG), an acidic lipid found in bacteria. Although the… CONTINUE READING
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