Interaction of a neutral endopeptidase inhibitor with an ANP-C receptor ligand in anesthetized dogs.

@article{Wegner1995InteractionOA,
  title={Interaction of a neutral endopeptidase inhibitor with an ANP-C receptor ligand in anesthetized dogs.},
  author={M E Wegner and J P Stasch and Claudia Hirth-Dietrich and Joachim Dressel and K P Voges and Stanislav Kazda},
  journal={Clinical and experimental hypertension},
  year={1995},
  volume={17 6},
  pages={861-76}
}
Inhibition of important degradative pathways of atrial natriuretic peptide (ANP) in vivo could be a valuable therapeutic tool for regulating endogenous levels of ANP. The aim was to investigate the in vivo effects of both blockade of atrial natriuretic peptide clearance receptor and inhibition of neutral endopeptidase 24.11, an enzyme shown to be involved in ANP breakdown. Therefore, we infused a specific neutral endopeptidase inhibitor ((S)-thiorphan) and an ANP-C receptor ligand (AP 811… CONTINUE READING

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