Interaction of a cyclin E fragment with Ku70 regulates Bax-mediated apoptosis.

  title={Interaction of a cyclin E fragment with Ku70 regulates Bax-mediated apoptosis.},
  author={Suparna Mazumder and Dragos C Plesca and Michael Kinter and Alexandru Almasan},
  journal={Molecular and cellular biology},
  volume={27 9},
The cyclin E/Cdk2 complex plays an essential role in the G(1)/S cell cycle transition and DNA replication. Earlier we showed that in hematopoietic tumor cells, caspase-mediated cleavage of cyclin E generates p18-cyclin E, which is unable to interact with Cdk2 and therefore plays a role independent of the cell cycle. The expression of a cleavage-resistant cyclin E mutant greatly diminishes apoptosis, indicating the critical role of cyclin E cleavage. p18-cyclin E expression can induce apoptosis… CONTINUE READING


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