Interaction of a cholera toxin derivative containing a reduced number of receptor binding sites with intact cells in culture.

@article{Wolf1994InteractionOA,
  title={Interaction of a cholera toxin derivative containing a reduced number of receptor binding sites with intact cells in culture.},
  author={M. D. De Wolf and E. Dams and W. Dierick},
  journal={Biochimica et biophysica acta},
  year={1994},
  volume={1223 2},
  pages={
          296-305
        }
}
Hybrid CTB (hCTB), having only one or two functional binding sites, has been constructed from two chemically inactivated derivatives of CTB. One inactive derivative consisted of CTB formylated in the lone Trp-88 of each beta-chain (fCTB), whereas the other inactive derivative consisted of CTB specifically succinylated in three amino groups located in or near the receptor binding site (sssCTB). hCTB, fCTB and sssCTB were able to reassociate with CTA and form the corresponding holotoxins hCT, fCT… Expand
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Vibrio cholerae: cholera toxin.

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