Interaction of Tetraethylammonium Ion Derivatives with the Potassium Channels of Giant Axons

@article{Armstrong1971InteractionOT,
  title={Interaction of Tetraethylammonium Ion Derivatives with the Potassium Channels of Giant Axons},
  author={Clay Armstrong},
  journal={The Journal of General Physiology},
  year={1971},
  volume={58},
  pages={413 - 437}
}
A number of compounds related to TEA(+) (tetraethylammoniumion) were injected into squid axons and their effects on g(K) (the potassium conductance) were determined. In most of these ions a quaternary nitrogen is surrounded by three ethyl groups and a fourth group that is very hydrophobic. Several of the ions cause inactivation of g(K), a type of ionic gating that is not normally seen in squid axon; i.e., after depolarization g(K) increases and then spontaneously decreases to a small fraction… CONTINUE READING
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