Interaction of Survival and Death Signaling in Basal Forebrain Neurons: Roles of Neurotrophins and Proneurotrophins

@article{Volosin2006InteractionOS,
  title={Interaction of Survival and Death Signaling in Basal Forebrain Neurons: Roles of Neurotrophins and Proneurotrophins},
  author={Marta Volosin and Wenyu Song and R. Almeida and D. Kaplan and B. Hempstead and W. Friedman},
  journal={The Journal of Neuroscience},
  year={2006},
  volume={26},
  pages={7756 - 7766}
}
  • Marta Volosin, Wenyu Song, +3 authors W. Friedman
  • Published 2006
  • Medicine, Biology
  • The Journal of Neuroscience
  • Proneurotrophins bind with high affinity to p75 neurotrophin receptor (p75NTR) and lack the capacity to bind Trk receptors, suggesting that proneurotrophins can elicit apoptosis via p75NTR even in cells expressing survival-promoting Trk receptors. In the CNS, basal forebrain (BF) neurons are particularly vulnerable to degeneration in Alzheimer’s disease, and are among the few populations of brain neurons that express p75NTR throughout life. These neurons also express Trk receptors and may be… CONTINUE READING
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