Interaction of St John's wort with low-dose oral contraceptive therapy: a randomized controlled trial.

@article{Pfrunder2003InteractionOS,
  title={Interaction of St John's wort with low-dose oral contraceptive therapy: a randomized controlled trial.},
  author={Arabelle Pfrunder and Monika Schiesser and S. Gerber and Manuel Haschke and Johannes Bitzer and Juergen Drewe},
  journal={British journal of clinical pharmacology},
  year={2003},
  volume={56 6},
  pages={
          683-90
        }
}
AIMS Breakthrough bleeding or even unwanted pregnancies have been reported in women during concomitant therapy with oral contraceptives and St John's wort extract. The aim of the present study was to investigate the effects of St John's wort extract on oral contraceptive therapy with respect to ovarian activity, breakthrough bleeding episodes and the pharmacokinetics of ethinyloestradiol and 3-ketodesogestrel. METHODS Eighteen healthy females were treated with a low-dose oral contraceptive (0… 
Interaction of St. John's Wort with oral contraceptives: effects on the pharmacokinetics of norethindrone and ethinyl estradiol, ovarian activity and breakthrough bleeding.
TLDR
St. John's Wort is associated with increased metabolism of norethindrone and ethinyl estradiol, breakthrough bleeding, follicle growth and ovulation, and women using OCs should be cautioned that St. Johns Wort might interfere with contraceptive effectiveness.
Co-administration of St. John's wort and hormonal contraceptives: a systematic review.
TLDR
Limited evidence showing increased risk of ovulation and breakthrough bleeding raises concern for decreased contraceptive efficacy when COCs are co-administered with SJW, and the pharmacokinetic evidence is mixed but suggests that SJW administration may be associated with weak to moderate induction of the metabolism of C OCs.
St John’s wort extract (Ze 117) does not alter the pharmacokinetics of a low-dose oral contraceptive
TLDR
The results indicate that the recommended dose of the hypericum extract Ze117, which has a low hyperforin content, does not interact with the pharmacokinetics of the hormonal components of the low-dose oral contraceptive.
Does St. John's wort interfere with the antiandrogenic effect of oral contraceptive pills?
TLDR
In women using OCPs and SJW simultaneously, it appears that SJW does not interfere with the antiandrogenic properties of O CPs.
The safety and efficacy of low-dose oral contraceptives
Abstract Oral contraceptives (OCs) are classified according to the dosage of ethinyloestradiol (EE) and type of progestogen, and whether the dosages of EE and progestogen stay the same during the
Clinical relevance of St. John's wort drug interactions revisited
TLDR
This review revisits the current knowledge of the mechanisms of action and on how pharmacokinetic drug interactions with SJW could be avoided and the degree of CYP3A4 induction correlates significantly with the hyperforin content in the preparation.
The safety and efficacy of low-dose oral
TLDR
There is no statistically significant difference in efficacy between highdose and low-dose OCs, and the 3 rd generation progestogens and antiandrogens are generally regarded as more “skin friendly”.
The safety and efficacy of low-dose oral contraceptives
TLDR
There is no statistically significant difference in efficacy between high-dose and low-dose OCs and several medications, such as rifampicin, some of the anticonvulsants and certain human immunodeficiency virus (HIV) medications, may reduce the efficacy of OCs.
Ovulation incidence with oral contraceptives: a literature review
TLDR
The findings indicate that COCs and the desogestrel POP are equally effective in suppressing ovulation, whilst the traditional POP formulations are less effective.
Interactions between preparations containing female sex hormones and dietary supplements.
TLDR
Taking preparations containing St John's wort during hormone therapy may lead to a reduction in hormone concentrations in serum and debilitation of the pharmacological effect.
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TLDR
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