Interaction of Sox1, Sox2, Sox3 and Oct4 during primary neurogenesis.

  title={Interaction of Sox1, Sox2, Sox3 and Oct4 during primary neurogenesis.},
  author={Tenley C. Archer and Jing Jin and Elena M Silva Casey},
  journal={Developmental biology},
  volume={350 2},
Sox1, Sox2 and Sox3, the three members of the SoxB1 subgroup of transcription factors, have similar sequences, expression patterns and overexpression phenotypes. Thus, it has been suggested that they have redundant roles in the maintenance of neural stem cells in development. However, the long-term effect of overexpression or their function in combination with their putative co-factor Oct4 has not been tested. Here, we show that overexpression of sox1, sox2, sox3 or oct91, the Xenopus homologue… CONTINUE READING
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