Interaction of SmpB with ribosome from directed hydroxyl radical probing

@inproceedings{Kurita2007InteractionOS,
  title={Interaction of SmpB with ribosome from directed hydroxyl radical probing},
  author={Daisuke Kurita and Rumi Sasaki and Akira Muto and Hyouta Himeno},
  booktitle={Nucleic acids research},
  year={2007}
}
To add a tag-peptide for degradation to the nascent polypeptide in a stalled ribosome, an unusual translation called trans-translation is facilitated by transfer-messenger RNA (tmRNA) having an upper half of the tRNA structure and the sequence encoding the tag-peptide except the first alanine. During this event, tmRNA enters the vacant A-site of the stalled ribosome without a codon-anticodon interaction, but with a protein factor SmpB. Here, we studied the sites and modes of binding of SmpB to… CONTINUE READING
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