Interaction of Sec4 with GDI proteins from bovine brain, Drosophila melanogaster and Saccharomyces cerevisiae. Conservation of GDI membrane dissociation activity.

@article{Garrett1993InteractionOS,
  title={Interaction of Sec4 with GDI proteins from bovine brain, Drosophila melanogaster and Saccharomyces cerevisiae. Conservation of GDI membrane dissociation activity.},
  author={M. Doolittle Dreier Duncan Dunn Ehlers Emerson Englis Garrett and Alisa K Kabcenell and J E Zahner and Kozo Kaibuchi and Takehiko Sasaki and Yoshimi Takai and Carolyn M. Cheney and Peter J. Novick},
  journal={FEBS letters},
  year={1993},
  volume={331 3},
  pages={233-8}
}
Rab GDP dissociation inhibitor (Rab GDI), will induce the dissociation of GDP-bound rab3A from synaptic membranes and will inhibit GDP dissociation from Sec4, a member of the Rab subgroup of the Ras GTPase superfamily which is required for exocytosis in Saccharomyces cerevisiae. We report that Rab GDI releases GDP-bound Sec4 from yeast membranes. dGDI, a Drosophila homologue can similarly inhibit GDP dissociation from Sec4 and release GDP-bound Sec4 from yeast membranes. An activity partially… CONTINUE READING

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