Interaction of SP-A (surfactant protein A) with bacterial rough lipopolysaccharide (Re-LPS), and effects of SP-A on the binding of Re-LPS to CD14 and LPS-binding protein.

@article{GarcaVerdugo2005InteractionOS,
  title={Interaction of SP-A (surfactant protein A) with bacterial rough lipopolysaccharide (Re-LPS), and effects of SP-A on the binding of Re-LPS to CD14 and LPS-binding protein.},
  author={Ignacio Garc{\'i}a-Verdugo and Fernando S{\'a}nchez-Barbero and Katrin Soldau and Peter S. Tobias and Cristina Casals},
  journal={The Biochemical journal},
  year={2005},
  volume={391 Pt 1},
  pages={115-24}
}
SP-A (surfactant protein A) is a lipid-binding collectin primarily involved in innate lung immunity. SP-A interacts with the bacterial rough LPS (lipopolysaccharide) Re-LPS (Re595 mutant of LPS from Salmonella minnesota), but not with smooth LPS. In the present study, we first examined the characteristics of the interaction of human SP-A with Re-LPS. Fluorescence intensity and anisotropy measurements of FITC-labelled Re-LPS in the presence and absence of SP-A indicated that SP-A bound to Re-LPS… CONTINUE READING
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