Interaction of SIGNR1 expressed by marginal zone macrophages with marginal zone B cells is essential to early IgM responses against Streptococcus pneumoniae.

@article{Koppel2008InteractionOS,
  title={Interaction of SIGNR1 expressed by marginal zone macrophages with marginal zone B cells is essential to early IgM responses against Streptococcus pneumoniae.},
  author={Estella A. Koppel and Manja Litjens and Venice C M van den Berg and Yvette van Kooyk and Teunis B H Geijtenbeek},
  journal={Molecular immunology},
  year={2008},
  volume={45 10},
  pages={2881-7}
}
The spleen plays a pivotal role in the immune defense against encapsulated bacteria such as Streptococcus pneumoniae. Murine splenic marginal zone macrophages express the C-type lectin SIGNR1, which is crucial for the capture of S. pneumoniae from blood. In this study, we demonstrate that SIGNR1 is able to interact in vitro with the juxtaposing marginal zone B cell population, which is responsible for the production of the early IgM response against the S. pneumoniae-epitope phosphorylcholine… CONTINUE READING

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