Interaction of RNA polymerase II fork loop 2 with downstream non-template DNA regulates transcription elongation.

@article{Kireeva2011InteractionOR,
  title={Interaction of RNA polymerase II fork loop 2 with downstream non-template DNA regulates transcription elongation.},
  author={Maria L. Kireeva and C{\'e}line Domecq and Benoit Coulombe and Zachary F Burton and Mikhail Kashlev},
  journal={The Journal of biological chemistry},
  year={2011},
  volume={286 35},
  pages={30898-910}
}
Fork loop 2 is a small semiconservative segment of the larger fork domain in the second largest Rpb2 subunit of RNA polymerase II (Pol II). This flexible loop, juxtaposed at the leading edge of transcription bubble, has been proposed to participate in DNA strand separation, translocation along DNA, and NTP loading to Pol II during elongation. Here we show that the Rpb2 mutant carrying a deletion of the flexible part of the loop is not lethal in yeast. The mutation exhibits no defects in DNA… CONTINUE READING

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1085–1099 Rpb2 Fork Loop 2 in Transcription

  • C. Zhang, Z. F. Burton
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