Interaction of Pseudomonas aeruginosa alkaline protease and elastase with human polymorphonuclear leukocytes in vitro.

@article{Kharazmi1984InteractionOP,
  title={Interaction of Pseudomonas aeruginosa alkaline protease and elastase with human polymorphonuclear leukocytes in vitro.},
  author={Arsalan Kharazmi and G. N. Doering and Niels H\oiby and Niels Henrik Valerius},
  journal={Infection and immunity},
  year={1984},
  volume={43 1},
  pages={161-5}
}
Little is known about the interaction of Pseudomonas aeruginosa extracellular products and human polymorphonuclear leukocytes. The present study was designed to examine the effect of alkaline protease and elastase purified from P. aeruginosa on human neutrophil function. Neutrophil chemotaxis, oxygen consumption, glucose oxidation, superoxide production, and nitro blue tetrazolium reduction were studied. It was found that alkaline protease and elastase at fairly low concentrations (0.05 and 0… CONTINUE READING