Interaction of PIP(2) with the XIP region of the cardiac Na/Ca exchanger.

@article{He2000InteractionOP,
  title={Interaction of PIP(2) with the XIP region of the cardiac Na/Ca exchanger.},
  author={Zhaoping He and Siyi Feng and Qiusheng Tong and Donald W Hilgemann and Kenneth D. Philipson},
  journal={American journal of physiology. Cell physiology},
  year={2000},
  volume={278 4},
  pages={C661-6}
}
The sarcolemmal Na/Ca exchanger undergoes an inactivation process in which exchange activity decays over several seconds following activation by the application of Na to the intracellular surface of the protein. Inactivation is eliminated by an increase in membrane phosphatidylinositol 4,5-bisphosphate (PIP(2)). Inactivation is also strongly affected by mutations to a basic 20-amino acid segment of the exchanger known as the endogenous XIP region. The hypothesis that PIP(2) directly interacts… CONTINUE READING