Corpus ID: 91693781

Interaction of Oxidative Stress and Inflammatory Response in Coronary Plaque Instability

  title={Interaction of Oxidative Stress and Inflammatory Response in Coronary Plaque Instability},
  author={SeiichiKobayashi and NobutakaInoue and YoshitakaOhashi and MitsuyoshiTerashima and KiyokoMatsui and TakaoMori and HidekiFujita and KojiroAwano and KatsuyaKobayashi and HiroshiAzumi and JunyaEjiri and Ken-ichiHirata and SeinosukeKawashima and YoshitakeHayashi and HiroshiYokozaki and HiroshiItoh and MitsuhiroYokoyama},
Objective— C-reactive protein (CRP), a predictor of cardiovascular events, localizes in atherosclerotic arteries and exerts proinflammatory effects on vascular cells. Reactive oxygen species (ROS) have been implicated in atherogenesis and plaque instability. Methods and Results— Expressional pattern of CRP in directional coronary atherectomy specimens from 39 patients was examined. Characteristics of histological plaque instability and higher levels of serum CRP and fibrinogen were associated… Expand
10 Citations
C-reactive protein decreases endothelial nitric oxide synthase activity via uncoupling.
  • 113
Human C-reactive protein and the metabolic syndrome
  • 194
C‐reactive protein induces M‐CSF release and macrophage proliferation
  • 50
C‐reactive protein and coronary composition in patients with percutaneous revascularization
  • 9
Role of C-Reactive Protein in Contributing to Increased Cardiovascular Risk in Metabolic Syndrome
  • 62
  • PDF