Interaction of Neuromuscular Blocking Effects ofNeomycin and Polymyxin B

  title={Interaction of Neuromuscular Blocking Effects ofNeomycin and Polymyxin B},
  author={C M Lee and A J de Silva},
Neomycin and polymyxin B produce neuromuscular blocks with distinct features by different mechanisms of action. In eight anesthetized cats the authors studied their interaction by examining the neuromuscular block produced by an equipotent mixture. Values of onset, potency, dose-response relations, duration and reversibility of block, the train-of-four and tetanic responses during block, the frequency-block relationships, and the posttetanic twitch behavior were well approximated by averaging… 
13 Citations

Antagonism of Org NC 45 Neuromuscular Blockade by Neostigmine, Pyridostigmine, and 4‐Aminopyridine

It is concluded that neostIGmine, pyridostigmine, and 4-aminopyridine effectively antagonize an Org NC 45 neuromuscular blockade.

Respiratory Muscle Paralysis Associated With Colistin, Polymyxin B, and Muscle Relaxants Drugs

A case of polymyxin B and E–induced apnea in a patient receiving “muscle relaxants” is reported, and it is reported that such a reaction might be enhanced by the presence of other classes of drugs.

Effects of aminoglycoside antibiotics on cholinergic autonomic nervous transmission.

The results suggest that the site for the block of aminoglycosides is mainly the cholinergic nerve terminal, where they reduce the available Ca ions required for the release of ACh.

Failure of neuromuscular blockade reversal after rocuronium in a patient who received oral neomycin

Rocuronium, a new nondepolarizing muscle relaxant, has potential interactions with other drugs including the aminoglycoside antibiotics and the antibiotiques aminosides avec the curares non dépolarisants.


This study determined and compared the potency and pharmacodynamic behaviour of vecuronium bromide, an intermediately long-acting nondepolarizing muscle relaxant, in the various paediatric age groups under similar anaesthetic conditions and using the same EMG method for quantitation of neuromuscular blockade.

Emerging considerations in the reversal of neuromuscular blockade and residual block

Early studies of the new compound, sugammadex has been shown to achieve a more rapid, stable reversal of steroidal based neuromuscular blocking agents compared to neostigmine, and has been demonstrated to be effective even when administered during profound neuromUScular block, without evidence of recurarization.

Effect of neomycin on post‐tetanic twitch tension of the mouse diaphragm preparation

  • M. Tsai
  • Biology, Medicine
    British journal of pharmacology
  • 1987
It is concluded that neomycin alters the conditions of tetanic stimulation inducing MTT and PTD of the indirectly elicited twitch tension.

Neurotoxic effects associated with antibiotic use: management considerations.

The clinical manifestations of antibiotic-induced neurotoxic effects, the underlying mechanisms and management strategies have been reviewed and high degree of vigilance in critically ill patients is essential in identifying a potentially serious, though reversible complications of antibiotic therapy.