Interaction of Mint2 with TrkA is involved in regulation of nerve growth factor-induced neurite outgrowth.

@article{Zhang2009InteractionOM,
  title={Interaction of Mint2 with TrkA is involved in regulation of nerve growth factor-induced neurite outgrowth.},
  author={Yong Zhang and Yonggang Wang and Qi Zhang and Xiu-jie Liu and Xuan Liu and Li Jiao and Wei Zhu and Zhao-huan Zhang and Xiao-lin Zhao and Cheng He},
  journal={The Journal of biological chemistry},
  year={2009},
  volume={284 18},
  pages={12469-79}
}
TrkA receptor signaling is essential for nerve growth factor (NGF)-induced survival and differentiation of sensory neurons. To identify possible effectors or regulators of TrkA signaling, yeast two-hybrid screening was performed using the intracellular domain of TrkA as bait. We identified muc18-1-interacting protein 2 (Mint2) as a novel TrkA-binding protein and found that the phosphotyrosine binding domain of Mint2 interacted with TrkA in a phosphorylation- and ligand-independent fashion… CONTINUE READING

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References

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Role of Interaction between TrkA and Mint2 12478 JOURNAL OF BIOLOGICAL CHEMISTRY VOLUME

A. D. Linstedt, A. Mehta, J. Suhan, H. Reggio, H. P. Hauri
MAY • 2009

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