Interaction of Mint2 with TrkA is involved in regulation of nerve growth factor-induced neurite outgrowth.

  title={Interaction of Mint2 with TrkA is involved in regulation of nerve growth factor-induced neurite outgrowth.},
  author={Yong Zhang and Yonggang Wang and Qi Zhang and Xiu-jie Liu and Xuan Liu and Li Jiao and Wei Zhu and Zhao-huan Zhang and Xiao-lin Zhao and Cheng He},
  journal={The Journal of biological chemistry},
  volume={284 18},
TrkA receptor signaling is essential for nerve growth factor (NGF)-induced survival and differentiation of sensory neurons. To identify possible effectors or regulators of TrkA signaling, yeast two-hybrid screening was performed using the intracellular domain of TrkA as bait. We identified muc18-1-interacting protein 2 (Mint2) as a novel TrkA-binding protein and found that the phosphotyrosine binding domain of Mint2 interacted with TrkA in a phosphorylation- and ligand-independent fashion… CONTINUE READING


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Publications referenced by this paper.

Role of Interaction between TrkA and Mint2 12478 JOURNAL OF BIOLOGICAL CHEMISTRY VOLUME

A. D. Linstedt, A. Mehta, J. Suhan, H. Reggio, H. P. Hauri
MAY • 2009

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