Interaction of Ler at the LEE5 (tir) operon of enteropathogenic Escherichia coli.

@article{Haack2003InteractionOL,
  title={Interaction of Ler at the LEE5 (tir) operon of enteropathogenic Escherichia coli.},
  author={Kenneth R Haack and Christopher L Robinson and Kristie J Miller and Jonathan W Fowlkes and Jay L. Mellies},
  journal={Infection and immunity},
  year={2003},
  volume={71 1},
  pages={384-92}
}
The genome of enteropathogenic Escherichia coli (EPEC) encodes a global regulator, Ler (locus of enterocyte effacement [LEE]-encoded regulator), which activates expression of several polycistronic operons within the 35.6-kb LEE pathogenicity island, including the LEE2-LEE3 divergent operon pair containing overlapping -10 regions and the LEE5 (tir) operon. Ler is a predicted 15-kDa protein that exhibits amino acid similarity with the nucleoid protein H-NS. In order to study Ler-mediated… CONTINUE READING