Interaction of LRRK2 with kinase and GTPase signaling cascades

Abstract

LRRK2 is a protein that interacts with a plethora of signaling molecules, but the complexity of LRRK2 function presents a challenge for understanding the role of LRRK2 in the pathophysiology of Parkinson's disease (PD). Studies of LRRK2 using over-expression in transgenic mice have been disappointing, however, studies using invertebrate systems have yielded… (More)
DOI: 10.3389/fnmol.2014.00064

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