Interaction of KAI1 on tumor cells with DARC on vascular endothelium leads to metastasis suppression

@article{Bandyopadhyay2006InteractionOK,
  title={Interaction of KAI1 on tumor cells with DARC on vascular endothelium leads to metastasis suppression},
  author={S. Bandyopadhyay and R. Zhan and A. Chaudhuri and M. Watabe and S. K. Pai and S. Hirota and S. Hosobe and T. Tsukada and K. Miura and Y. Takano and K. Saito and M. Pauza and Sunao Hayashi and Y. Wang and S. Mohinta and T. Mashimo and Megumi Iiizumi and E. Furuta and K. Watabe},
  journal={Nature Medicine},
  year={2006},
  volume={12},
  pages={933-938}
}
CD82, also known as KAI1, was recently identified as a prostate cancer metastasis suppressor gene on human chromosome 11p1.2 (ref. 1). The product of CD82 is KAI1, a 40- to 75-kDa tetraspanin cell-surface protein also known as the leukocyte cell-surface marker CD82 (refs. 1,2). Downregulation of KAI1 has been found to be clinically associated with metastatic progression in a variety of cancers, whereas overexpression of CD82 specifically suppresses tumor metastasis in various animal models. To… Expand
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