Interaction of Ia antigen-bearing polymorphonuclear leukocytes and murine splenocytes

  title={Interaction of Ia antigen-bearing polymorphonuclear leukocytes and murine splenocytes},
  author={Dr. John E. Fitzgerald and Stephen T. Sonis and Mary L. Rodrick and Richard E. Wilson},
Polymorphonuclear leukocytes (PMN) were induced in the peritoneum of a Balb/c mouse by ip injection ofFusobacterium nucleatum (FN) (>95% PMN). A subpopulation of PMN harvested bore Ia surface antigens and stimulated a mixed lymphocyte reaction (MLR) when cultured with C57B1 /6J splenocytes. The reaction was blocked by a short prior incubation of PMN with anti-Ia antibody or PMN cell depletion by the same antibody plus complement. The Ia antigen-bearing PMN were capable of antigenic modulation… CONTINUE READING
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