Interaction of HIV-1 integrase with DNA repair protein hRad18.

  title={Interaction of HIV-1 integrase with DNA repair protein hRad18.},
  author={Lubbertus C. F. Mulder and Lisa A Chakrabarti and Mark A. Muesing},
  journal={The Journal of biological chemistry},
  volume={277 30},
We have previously shown that human immunodeficiency virus-1 (HIV-1) integrase is an unstable protein and a substrate for the N-end rule degradation pathway. This degradation pathway shares its ubiquitin-conjugating enzyme, Rad6, with the post-replication/translesion DNA repair pathway. Because DNA repair is thought to play an essential role in HIV-1 integration, we investigated whether other molecules of this DNA repair pathway could interact with integrase. We observed that co-expression of… CONTINUE READING

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