Interaction of HIV-1 Tat protein with heparin. Role of the backbone structure, sulfation, and size.

@article{Rusnati1997InteractionOH,
  title={Interaction of HIV-1 Tat protein with heparin. Role of the backbone structure, sulfation, and size.},
  author={Marco Rusnati and Daniela Coltrini and Pasqua Oreste and Giorgio Zoppetti and Adriana Albini and Daniel W. Noonan and F d'Adda di Fagagna and Mauro Giacca and Marco Presta},
  journal={The Journal of biological chemistry},
  year={1997},
  volume={272 17},
  pages={11313-20}
}
Human immunodeficiency virus type 1 (HIV-1) Tat protein is released from infected cells. Extracellular Tat enters the cell where it stimulates the transcriptional activity of HIV-long terminal repeat (LTR) and of endogenous genes. Heparin modulates the angiogenic (Albini, A., Benelli, R., Presta, M., Rusnati, M., Ziche, M., Rubartelli, A., Paglialunga, G., Bussolino, F., and Noonan, D. (1996) Oncogene 12, 289-297) and transcriptional (Mann, D. A., and Frankel, A. D. (1991) EMBO J. 10, 1733-1739… CONTINUE READING