Interaction of HIV-1 Nef with the cellular dileucine-based sorting pathway is required for CD4 down-regulation and optimal viral infectivity.

@article{Craig1998InteractionOH,
  title={Interaction of HIV-1 Nef with the cellular dileucine-based sorting pathway is required for CD4 down-regulation and optimal viral infectivity.},
  author={Heather M. Craig and Mark W. Pandori and John Guatelli},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1998},
  volume={95 19},
  pages={11229-34}
}
The HIV-1 Nef protein is important for pathogenesis, enhances viral infectivity, and regulates the sorting of at least two cellular transmembrane proteins, CD4 and major histocompatibility complex (MHC) class I. Although several lines of evidence support the hypothesis that the Nef protein interacts directly with the cellular protein sorting machinery, the sorting signal in HIV-1 Nef has not been identified. By using a competition assay that functionally discriminates between dileucine-based… CONTINUE READING
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  • J. Hua, W. Blair, R. Truant, Cullen, B. R. Virology 231, 231–238. 11234 Cell Biology
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