Corpus ID: 38193661

Interaction of Ginkgo biloba extract (GBE) with hypotensive agent, nicardipine, in rats.

  title={Interaction of Ginkgo biloba extract (GBE) with hypotensive agent, nicardipine, in rats.},
  author={Y. Kubota and K. Kobayashi and Naoka Tanaka and Kazuki Nakamura and M. Kunitomo and K. Umegaki and K. Shinozuka},
  journal={In vivo},
  volume={17 5},
  • Y. Kubota, K. Kobayashi, +4 authors K. Shinozuka
  • Published 2003
  • Medicine
  • In vivo
  • The effect of Ginkgo biloba extract (GBE, 0.5%) orally administered for 2 weeks on the antihypertensive action of oral nicardipine was examined in Wistar rats. GBE significantly increased hepatic P-450 content and reduced the hypotensive effect of nicardipine. GBE administration resulted in a significant decrease in maximal nicardipine plasma concentration (Cmax) and the 23-hour area under the curve (AUC0-23). Thus, it is suggested that GBE attenuated the therapeutic potency of nicardipine… CONTINUE READING
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