Interaction of GABA and volatile anesthetics in the nematode Caenorhabditis elegans.

  title={Interaction of GABA and volatile anesthetics in the nematode Caenorhabditis elegans.},
  author={Mark V. Boswell and Philip G Morgan and Margaret M Sedensky},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  volume={4 8},
  • M. Boswell, P. Morgan, M. Sedensky
  • Published 1 September 1989
  • Medicine
  • FASEB journal : official publication of the Federation of American Societies for Experimental Biology
The authors tested whether mutant strains of Caenorhabditis elegans with altered sensitivity to volatile anesthetics have altered responses to GABA or GABA-agonists. They determined the ED50s of the wild-type strain N2 and two mutant strains of C. elegans to a GABA-mimetic ivermectin (IVM) and to GABA. unc-79, a strain with increased sensitivity to halothane, was more sensitive than N2 to IVM and GABA. unc-9, a strain that suppresses the increased sensitivity of unc-79 to halothane, was less… 
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Understanding anthelmintic resistance: the need for genomics and genetics.
  • J. Gilleard
  • Biology, Medicine
    International journal for parasitology
  • 2006
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