Interaction of GABA and volatile anesthetics in the nematode Caenorhabditis elegans.

@article{Boswell1990InteractionOG,
  title={Interaction of GABA and volatile anesthetics in the nematode Caenorhabditis elegans.},
  author={Mark V. Boswell and Philip G Morgan and Margaret M Sedensky},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={1990},
  volume={4 8},
  pages={
          2506-10
        }
}
  • M. Boswell, P. Morgan, M. Sedensky
  • Published 1 September 1989
  • Medicine
  • FASEB journal : official publication of the Federation of American Societies for Experimental Biology
The authors tested whether mutant strains of Caenorhabditis elegans with altered sensitivity to volatile anesthetics have altered responses to GABA or GABA-agonists. They determined the ED50s of the wild-type strain N2 and two mutant strains of C. elegans to a GABA-mimetic ivermectin (IVM) and to GABA. unc-79, a strain with increased sensitivity to halothane, was more sensitive than N2 to IVM and GABA. unc-9, a strain that suppresses the increased sensitivity of unc-79 to halothane, was less… 
The Caenorhabditis elegans Avermectin Resistance and Anesthetic Response Gene unc‐9 Encodes a Member of a Protein Family Implicated in Electrical Coupling of Excitable Cells
TLDR
It is shown that alteration of highly conserved proline residues in UNC‐9 leads to a cold sensitivity that likely affects a step in protein expression rather than function, and speculation on the basis of the avermectin resistance and anesthetic response phenotypes is speculated.
What canCaenorhabditis elegans tell us about nematocides and parasites?
TLDR
Information acquired from Caenorhabditis elegans can be usefully applied to understand the mechanisms of drug sensitivity and the genetics of resistance in parasites.
Anesthetic Interaction Between Midazolam and Halothane in Humans
TLDR
The results indicate that midazolam produces marked reduction of halothane MAC in humans at Serum concentrations lower than that required to cause sleep, and midrazolam's Dotentiation of Halothane has a saturated nature.
Characterization of Stomatin Suppressors ssu-1 AND ssu-2
The mechanism of volatile anesthetics remains unknown. In C. elegans, the gene unc-1 affects anesthetic sensitivity and normal locomotion. The neuronal-expressed UNC-1 belongs to a large family of
Clonidine and Dexmedetomidine Produce Antinociceptive Synergy in Mouse Spinal Cord
TLDR
The current study introduces a new synergistic agonist pair, clonidine–dexmedetomidine, which seems to require the &agr;2AAR for spinal analgesia when given separately; when delivered as a combination, the resultant synergistic interaction requires the &ags;2CAR as well.
Understanding anthelmintic resistance: the need for genomics and genetics.
  • J. Gilleard
  • Biology, Medicine
    International journal for parasitology
  • 2006
TLDR
The application of forward genetic and functional genomic approaches to the analysis of benzimidazole and ivermectin resistance is reviewed and the reasons for their relative success or failure are discussed.
Antinociceptive Interaction of Intrathecal α2‐adrenergic Agonists, Tizanidine and Clonidine, with Lidocaine in Rats
TLDR
It is shown that intrathecal tizanidine and clonidine synergistically interact with lidocaine so that the degree of antinociception to somatic noxious stimuli are enhanced.
The anti-nociceptive and cardiopulmonary effects of extradural fentanyl-xylazine in sheep.
TLDR
Fentanyl decreases the onset time and prolongs the duration of anti-nociception produced by xylazine, and the combination decreases cardiac output but is without significant respiratory effects.
The role of clonidine and alpha2-agonists for postoperative analgesia
TLDR
Clonidine is a selective partial agonist for ~2-adrenoceptors with a ratio of approximately 220:1 (et 2 : oq), and is rapidly absorbed after oral administration and reaches peak plasma concentrations within 60 to 90 rain.
Role of Signal Transduction in Anesthetic Action
The molecular mechanism for general anesthetic action is not known. The alpha 2 adrenergic agonists represent a novel class of "anesthetic-like" agent because of their selectivity for receptor
...
1
2
3
4
5
...