Interaction of Frizzled 7 and Dishevelled in Xenopus.

  title={Interaction of Frizzled 7 and Dishevelled in Xenopus.},
  author={Araceli Medina and Herbert Steinbeisser},
  journal={Developmental dynamics : an official publication of the American Association of Anatomists},
  volume={218 4},
Frizzled proteins act as putative Wnt receptors and depending on Wnt/Frizzled interactions distinct intracellular pathways can be activated. The canonical Wnt pathway, triggered by Wnt-1-type ligands, is the best characterized and involves the activation of the cytoplasmic protein Dishevelled (Dsh). The Xenopus frizzled 7 receptor (Xfz7) can act in the canonical (Wnt-1-type) as well as in a non-canonical Wnt pathway which involves the activation of protein kinase C (PKC). In order to analyze… CONTINUE READING

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