Interaction of Fc receptor (CD16) ligands induces transcription of interleukin 2 receptor (CD25) and lymphokine genes and expression of their products in human natural killer cells

@article{Anegn1988InteractionOF,
  title={Interaction of Fc receptor (CD16) ligands induces transcription of interleukin 2 receptor (CD25) and lymphokine genes and expression of their products in human natural killer cells},
  author={Ignacio Aneg{\'o}n and Maria Cristina Cuturi and Giorgio Wynnewood Trinchieri and Bice Perussia},
  journal={The Journal of Experimental Medicine},
  year={1988},
  volume={167},
  pages={452 - 472}
}
We report evidence that FcR(CD16) on human NK cells are signal-transducing molecules that, upon ligand binding, induce transcription of genes encoding surface activation molecules [IL-2-R(CD25)] and cytokines (IFN-gamma and TNF) relevant to NK cell biology and functions. Homogeneous NK and T cell populations purified from short-term bulk cultures of PBMC with irradiated B lymphoblastoid cell lines were cultured in the presence of FcR ligands (particulate immune complexes or immobilized anti… CONTINUE READING

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References

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SHOWING 1-5 OF 5 REFERENCES

Stimulated mobilization ofmonocyte Mac-1 and p150,95 adhesion proteins from an intracellular vesicular compartment to the cell surface .J

Miller, J L., D . F . Bainton, N . Borregaard, T. A . Springer
  • Clin. Invest
  • 1987

Tumor necrosis factor-a enhances cytolytic activity of human Natural Killer cells.

Ostensen, E M., D . L . Thiele, P . E . Lipsky
  • Immunol
  • 1987

Monoclona l antibodies to Fc receptors for IgG on human mononuclear phagocytes : antibody characterization and induction of superoxide production in a monocyte cell line

Fanger
  • J. Biol . Chem
  • 1986

gism with immune interferon

C .-C, B . Perussia, A. Cohn, J . D.-E Young
  • .J. Exp . Med
  • 1986