Interaction of FKBP5 with Childhood Adversity on Risk for Post-Traumatic Stress Disorder

@article{Xie2010InteractionOF,
  title={Interaction of FKBP5 with Childhood Adversity on Risk for Post-Traumatic Stress Disorder},
  author={P. Xie and H. Kranzler and James Poling and M. Stein and R. Anton and L. Farrer and J. Gelernter},
  journal={Neuropsychopharmacology},
  year={2010},
  volume={35},
  pages={1684-1692}
}
FKBP5 regulates the cortisol-binding affinity and nuclear translocation of the glucocorticoid receptor. Polymorphisms at the FKBP5 locus have been associated with increased recurrence risk of depressive episodes and rapid response to antidepressant treatment. A recent study showed that FKBP5 genotypes moderated the risk of post-traumatic stress disorder (PTSD) symptoms associated with childhood maltreatment. One thousand one hundred forty-three European Americans (EAs) and 1284 African… Expand
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