Interaction of F1L with the BH3 domain of Bak is responsible for inhibiting vaccinia-induced apoptosis

@article{Postigo2006InteractionOF,
  title={Interaction of F1L with the BH3 domain of Bak is responsible for inhibiting vaccinia-induced apoptosis},
  author={Antonio L{\'o}pez Postigo and Justin Robert Cross and Julian Downward and Michael Way},
  journal={Cell Death & Differentiation},
  year={2006},
  volume={13},
  pages={1651-1662}
}
Apoptosis represents an important cellular defence mechanism against viral pathogens by virtue of its ability to remove infected cells. Consequently, many viruses have developed numerous strategies to prevent or delay host cell apoptosis in order to achieve productive replication. Here we report that deletion of the F1L gene from the vaccinia genome results in increased apoptosis during infection. We demonstrate that F1L, which has no sequence homology to Bcl-2 family members, inhibits… CONTINUE READING
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