Interaction of E1 and E3 components with the core proteins of the human pyruvate dehydrogenase complex.

@article{Patel2009InteractionOE,
  title={Interaction of E1 and E3 components with the core proteins of the human pyruvate dehydrogenase complex.},
  author={Mulchand S. Patel and Lioubov G. Korotchkina and Sukhdeep Sidhu},
  journal={Journal of molecular catalysis. B, Enzymatic},
  year={2009},
  volume={61 1-2},
  pages={2-6}
}
The human (h) pyruvate dehydrogenase complex (hPDC) consists of multiple copies of several components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2), dihydrolipoamide dehydrogenase (E3), E3-binding protein (BP), and specific kinases and phosphatases. Mammalian PDC has a well organized structure with an icosahedral symmetry of the central E2/BP core to which the other component proteins bind non-covalently. Both hE2 and hBP consist of three well defined domains, namely the… CONTINUE READING

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