Interaction of Docetaxel (“Taxotere”) with Human P‐Glycoprotein

@inproceedings{Shirakawa1999InteractionOD,
  title={Interaction of Docetaxel (“Taxotere”) with Human P‐Glycoprotein},
  author={Katsuro Shirakawa and Kohji Takara and Yusuke Tanigawara and Nobuo Aoyama and Masato Kasuga and Fusao Komada and Toshiyuki Sakaeda and Katsuhiko Okumura},
  booktitle={Japanese journal of cancer research : Gann},
  year={1999}
}
The interaction of docetaxel ("Taxotere") with P-glycoprotein (P-gp) was examined using porcine kidney epithelial LLC-PK1 and LLC-GA5-COL150 cells, overexpressing human P-gp selectively on the apical plasma membrane by transfection of human MDR1 cDNA into the LLC-PK1 cells. The basal-to-apical transport of [14C]docetaxel in LLC-GA5-COL150 cells significantly exceeded that in LLC-PK1 cells, but the apical-to-basal transport was decreased in LLC-GA5-COL150 cells. The intracellular accumulation… CONTINUE READING