• Chemistry, Medicine
  • Published in Arzneimittel-Forschung 1979

Interaction of DL-, D- and L-propranolol with the transport system of glucose in human erythrocytes.

@article{Lacko1979InteractionOD,
  title={Interaction of DL-, D- and L-propranolol with the transport system of glucose in human erythrocytes.},
  author={Ladislav Lacko and Barbara Wittke and Ivan Lacko},
  journal={Arzneimittel-Forschung},
  year={1979},
  volume={29 11},
  pages={
          1685-7
        }
}
The effect of D-, L- and DL-propranolol on the glucose uptake in human erythrocytes was studied. It was observed that all three compounds competitively inhibit the glucose transport and have identical inhibition constants. The pH dependence of the inhibition constant indicates that uncharged propranolol is a more potent inhibitor than the charged one. The thermodynamic parameters of the interaction of propranolol with the glucose transport system were determined and discussed. 

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