Interaction of Clostridium perfringens delta toxin with erythrocyte and liposome membranes and relation with the specific binding to the ganglioside GM2.

@article{JolivetReynaud1989InteractionOC,
  title={Interaction of Clostridium perfringens delta toxin with erythrocyte and liposome membranes and relation with the specific binding to the ganglioside GM2.},
  author={Colette Jolivet-Reynaud and Bernard Hauttecoeur and Joseph E. Alouf},
  journal={Toxicon : official journal of the International Society on Toxinology},
  year={1989},
  volume={27 10},
  pages={1113-26}
}
The specific interaction of the cytolytic Clostridium perfringens delta toxin with membrane GM2 was indicated by: (i) characterization of this glycolipid in the membrane of sheep and goat erythrocytes, which are lysed by the toxin, whereas GM2 was undetectable in insensitive rabbit erythrocytes, (ii) demonstration of 125I-toxin binding to GM2, by autoradiography, following incubation with thin-layer chromatograms containing separated neuroblastoma gangliosides, and (iii) toxin fixation by… CONTINUE READING
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