Interaction of Cisplatin with the human organic cation transporter 2.

@article{Filipski2008InteractionOC,
  title={Interaction of Cisplatin with the human organic cation transporter 2.},
  author={Kelly K Filipski and Walter J. Loos and Jaap Verweij and Alex Sparreboom},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2008},
  volume={14 12},
  pages={3875-80}
}
PURPOSE Cisplatin is predominantly eliminated in the urine through active secretion. As the solute carrier organic cation transporter 2 (OCT2) is highly expressed in the basolateral membrane of proximal tubules, we determined its contribution to cisplatin transport and assessed the relation of variation in the gene encoding OCT2 (SLC22A2) with the disposition of cisplatin. EXPERIMENTAL DESIGN Cell lines were transfected using the Flp-In 293 system with the full-length OCT2 cDNA, and platinum… CONTINUE READING