Interaction of Ca-channel blockers and high pressure at the crustacean neuromuscular junction.

@article{Grossman1991InteractionOC,
  title={Interaction of Ca-channel blockers and high pressure at the crustacean neuromuscular junction.},
  author={Yoram Grossman and Joel S. Colton and Sara C. Gilman},
  journal={Neuroscience letters},
  year={1991},
  volume={125 1},
  pages={53-6}
}
Exposure to high pressure causes a significant depression of synaptic transmission. We examined the effects of various Ca-channel blockers and their interaction with high pressure on excitatory neuromuscular junction currents (EJCs) of lobster abdominal muscles. Reduced [Ca2+]o to half of normal concentration or exposure to 40-60 microM CdCl2, 10-20 microM NiCl2 and 1 microM omega-conotoxin decreased EJCs by 50%. Nifedipine, Nitrendipine and Bay K-8644 were ineffective. Either Ca-blockers or… CONTINUE READING
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