Interaction of CK1δ with γTuSC ensures proper microtubule assembly and spindle positioning

@inproceedings{Peng2015InteractionOC,
  title={Interaction of CK1δ with γTuSC ensures proper microtubule assembly and spindle positioning},
  author={Yutian Peng and Michelle Moritz and Xuemei Han and Thomas H. Giddings and Andrew Stolfus Lyon and Justin M Kollman and Mark Winey and John R. Yates and David A. Agard and David G Drubin and Georjana Barnes and Kerry S. Bloom},
  booktitle={Molecular biology of the cell},
  year={2015}
}
Casein kinase 1δ (CK1δ) family members associate with microtubule-organizing centers (MTOCs) from yeast to humans, but their mitotic roles and targets have yet to be identified. We show here that budding yeast CK1δ, Hrr25, is a γ-tubulin small complex (γTuSC) binding factor. Moreover, Hrr25's association with γTuSC depends on its kinase activity and its noncatalytic central domain. Loss of Hrr25 kinase activity resulted in assembly of unusually long cytoplasmic microtubules and defects in… CONTINUE READING

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