Interaction of CDK5RAP2 with EB1 to track growing microtubule tips and to regulate microtubule dynamics.

@article{Fong2009InteractionOC,
  title={Interaction of CDK5RAP2 with EB1 to track growing microtubule tips and to regulate microtubule dynamics.},
  author={K N Fong and Shiu-Yeung Hau and Yik-Shing Kho and Yue Xia Jia and Lisheng He and Robert Z. Qi},
  journal={Molecular biology of the cell},
  year={2009},
  volume={20 16},
  pages={
          3660-70
        }
}
Mutations in cdk5rap2 are linked to autosomal recessive primary microcephaly, and attention has been paid to its function at centrosomes. In this report, we demonstrate that CDK5RAP2 localizes to microtubules and concentrates at the distal tips in addition to centrosomal localization. CDK5RAP2 interacts directly with EB1, a prototypic member of microtubule plus-end tracking proteins, and contains the basic and Ser-rich motif responsible for EB1 binding. The EB1-binding motif is conserved in the… CONTINUE READING

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