Interaction of C-reactive protein with artificial phosphatidylcholine bilayers

  title={Interaction of C-reactive protein with artificial phosphatidylcholine bilayers},
  author={John E. Volanakis and Karel W. A. Wirtz},
C-Reactive protein (CRP), the most characteristic of the ‘acute phase proteins’ (ref. 1) is thought to participate in the mediation and/or modulation of acute inflammatory processes, but its exact function is unknown. CRP has a Ca2+-dependent binding specificity for phosphorylcholine,2 the polar head group of two widely distributed lipids, lecithin (phosphatidylcholine, PC) and sphingomyelin (SM). A number of observations3–5 suggest that at least some of the biological activities of CRP depend… CONTINUE READING
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