Interaction of Bivalent Ligand KDN 21 with Heterodimeric-Opioid Receptors in Human Embryonic Kidney 293 Cells

@inproceedings{Xie2005InteractionOB,
  title={Interaction of Bivalent Ligand KDN 21 with Heterodimeric-Opioid Receptors in Human Embryonic Kidney 293 Cells},
  author={Zhihua Xie and Rashmi Gupta Bhushan and David J. Daniels and Philip S. Portoghese},
  year={2005}
}
KDN21 is a bivalent ligand that contains and opioid antagonist pharmacophores linked through a 21-atom spacer. It has been reported that KDN21 bridges and receptors that are organized as heterodimers. We have shown previously that when using [H]diprenorphine as radioligand, KDN21 displayed greatly enhanced affinity in this series for coexpressed and opioid receptors (CDK). The present study used in vitro expression systems to investigate interactions of members of the KDN series with… CONTINUE READING

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