Interaction of BTG1 and p53-regulated BTG2 gene products with mCaf1, the murine homolog of a component of the yeast CCR4 transcriptional regulatory complex.

@article{Rouault1998InteractionOB,
  title={Interaction of BTG1 and p53-regulated BTG2 gene products with mCaf1, the murine homolog of a component of the yeast CCR4 transcriptional regulatory complex.},
  author={Jean Pierre Rouault and D{\'e}borah Pr{\'e}v{\^o}t and Cyril Berthet and Anne Marie Birot and Marc Billaud and Jean Pierre Magaud and Laura Corbo},
  journal={The Journal of biological chemistry},
  year={1998},
  volume={273 35},
  pages={
          22563-9
        }
}
Both BTG1 and BTG2 are involved in cell-growth control. BTG2 expression is regulated by p53, and its inactivation in embryonic stem cells leads to the disruption of DNA damage-induced G2/M cell-cycle arrest. In order to investigate the mechanism underlying Btg-mediated functions, we looked for possible functional partners of Btg1 and Btg2. Using yeast two-hybrid screening, protein-binding assays, and transient transfection assays in HeLa cells, we demonstrated the physical in vitro and in vivo… CONTINUE READING

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