Interaction of BP180 (type XVII collagen) and alpha6 integrin is necessary for stabilization of hemidesmosome structure.

@article{Hopkinson1998InteractionOB,
  title={Interaction of BP180 (type XVII collagen) and alpha6 integrin is necessary for stabilization of hemidesmosome structure.},
  author={Susan B Hopkinson and Kim Findlay and Gregory W Dehart and Jonathan C R Jones},
  journal={The Journal of investigative dermatology},
  year={1998},
  volume={111 6},
  pages={1015-22}
}
The hemidesmosome is a multimolecular complex that integrates the extracellular matrix with the keratin cytoskeleton and that stabilizes epithelial attachment to connective tissue. A 180 kDa protein (BP180, type XVII collagen), first identified by its reactivity with autoantibodies in the serum of patients with a blistering skin disease called bullous pemphigoid (BP), is a transmembrane component of the hemidesmosome with a collagen-like extracellular domain. Here, using recombinantly expressed… CONTINUE READING
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