Interaction of Arabidopsis DET1 with CCA1 and LHY in mediating transcriptional repression in the plant circadian clock.

@article{Lau2011InteractionOA,
  title={Interaction of Arabidopsis DET1 with CCA1 and LHY in mediating transcriptional repression in the plant circadian clock.},
  author={On Sun Lau and Xi Huang and J F Charron and Jae-Hoon Lee and Gang Li and Xing Wang Deng},
  journal={Molecular cell},
  year={2011},
  volume={43 5},
  pages={703-12}
}
The COP10-DET1-DDB1 (CDD) complex is an evolutionarily conserved protein complex discovered for its role in the repression of photomorphogenesis in Arabidopsis. It is important in many cellular and developmental processes in both plants and animals, but its molecular mode of action remains poorly understood. Here, we show that the CDD component DET1 possesses transcriptional repression activity and physically interacts with two closely related MYB transcription factors, CCA1 and LHY, which are… CONTINUE READING