Interaction of Amyloid Beta-Protein with Anionic Phospholipids: Possible Involvement of Lys28 and C-Terminus Aliphatic Amino Acids

@article{Chauhan2000InteractionOA,
  title={Interaction of Amyloid Beta-Protein with Anionic Phospholipids: Possible Involvement of Lys28 and C-Terminus Aliphatic Amino Acids},
  author={Abha Chauhan and Indrani Ray and Ved P. S. Chauhan},
  journal={Neurochemical Research},
  year={2000},
  volume={25},
  pages={423-429}
}
Fibrillar amyloid beta-protein (Aβ) is the major protein of amyloid plaques in the brains of patients with Alzheimer's disease (AD). The mechanism by which normally produced soluble Aβ gets fibrillized in AD is not clear. We studied the effect of neutral, zwitterionic, and anionic lipids on the fibrillization of Aβ 1-40. We report here that acidic… CONTINUE READING